An IP receptor agonist (Ki = 3 nM); selective for IP over DP1 and EP1-4 (Kis = 2

Ralinepag – 10 mg

Brand:
Cayman
CAS:
1187856-49-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ralinepag is a prostaglandin I2 (PGI2) receptor (IP) agonist (Ki = 3 nM).{50853} It is selective for IP over the PGD2 receptor (DP1) and the PGE2 receptor subtypes EP1-4 (Kis = 2,600, 9,600, 611, 143, and 678 nM, respectively, in radioligand binding assays). Ralinepag induces cAMP accumulation in CHO-K1 cells expressing human recombinant IP (EC50 = 8.5 nM). In vivo, ralinepag (30 mg/kg) prevents increases in pulmonary arterial pressure and vessel wall thickness in a rat model of monocrotaline-induced pulmonary arterial hypertension.  

 

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SKU: 30009 - 10 mg Category:

Description

An IP receptor agonist (Ki = 3 nM); selective for IP over DP1 and EP1-4 (Kis = 2,600, 9,600, 611, 143, and 678 nM, respectively, in radioligand binding assays); induces cAMP accumulation in CHO-K1 cells expressing human recombinant IP (EC50 = 8.5 nM); prevents increases in pulmonary arterial pressure and vessel wall thickness in a rat model of monocrotaline-induced pulmonary arterial hypertension at 30 mg/kg

Formal name: 2-[[trans-4-[[[[(4-chlorophenyl)phenylamino]carbonyl]oxy]methyl]cyclohexyl]methoxy]-acetic acid

Synonyms: 

Molecular weight: 431.9

CAS: 1187856-49-0

Purity: ≥95%

Formulation: A solid

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