Description
The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK.{14542} Previous studies have shown that phosphorylation is required for Raf-1 activation.{14329,14539} Recent work has demonstrated that phosphorylation also regulates the down regulation of Raf with two sites participating: Ser301 and Ser642.{14540}
Synonyms:
Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1
Formulation: Affinity-purified IgG
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling
