A NR2B subunit-containing NMDA receptor antagonist (IC50 = 8 nM); selective for NR2B subunit-containing NMDA receptors over NR1 and NR2A subunit-containing NMDA receptors at 15 µM; reduces amyloid β (1-42) (Aβ42) and Aβ40-induced decreases in dendritic spine density in mouse hippocampal CA1 pyramidal neurons at 10 nM; restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson's disease at 2 mg/kg

Radiprodil – 5 mg

Brand:
Cayman
CAS:
496054-87-6
Storage:
-20
UN-No:
Non-Hazardous - /

Radiprodil is an antagonist of NR2B subunit-containing NMDA receptors (IC50 = 8 nM).{52284} It is selective for NR2B subunit-containing NMDA receptors over NR1 and NR2A subunit-containing NMDA receptors at 15 µM. Radiprodil (10 nM) reduces amyloid β (1-42) (Aβ42) and Aβ40-induced decreases in dendritic spine density in mouse hippocampal CA1 pyramidal neurons.{52285} Radiprodil (2 mg/kg) restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease.{47789}  

 

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SKU: 29712 - 5 mg Category:

Description

A NR2B subunit-containing NMDA receptor antagonist (IC50 = 8 nM); selective for NR2B subunit-containing NMDA receptors over NR1 and NR2A subunit-containing NMDA receptors at 15 µM; reduces amyloid β (1-42) (Aβ42) and Aβ40-induced decreases in dendritic spine density in mouse hippocampal CA1 pyramidal neurons at 10 nM; restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson’s disease at 2 mg/kg

Formal name: N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-[(4-fluorophenyl)methyl]-α-oxo-1-piperidineacetamide

Synonyms: 

Molecular weight: 397.4

CAS: 496054-87-6

Purity: ≥98%

Formulation: A solid

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