An inhibitor of Hsp90 (IC50 = erb82

Radicicol – 500 µg

Brand:
Cayman
CAS:
12772-57-5
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Radicicol is an inhibitor of heat shock protein 90 (Hsp90; IC50 = erb82, and mutant p53.{16758,16759} Radicicol also binds to and inhibits DNA topoisomerase type II proteins and GRP94 through an ATPase domain common to Hsp90.{16758,16756}  

 

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Description

An inhibitor of Hsp90 (IC50 = erb82, and mutant p53; binds to and inhibits DNA topoisomerase type II proteins and GRP94

Formal name: (4E)-8-chloro-1aR,14R,15,15aR-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2Z]benzoxacyclotetradecin-6,12(7H)-dione

Synonyms:  KF58332|KF9-A|Monorden|NSC 294404

Molecular weight: 364.7

CAS: 12772-57-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|Cellular Chaperones||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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