An oxazolidinone antibiotic; active against a variety of bacterial clinical isolates (MICs = ≤0.25-64 µg/ml); active against L. monocytogenes

Radezolid – 1 mg

Brand:
Cayman
CAS:
869884-78-6
Storage:
-20
UN-No:
Non-Hazardous - /

Radezolid is an oxazolidinone antibiotic and a derivative of linezolid (Item No. 15012).{46800} It is active against a variety of bacterial clinical isolates, including strains of methicillin-sensitive and -resistant S. aureus, vancomycin-sensitive and -resistant E. faecalis and E. faecium, and linezolid-resistant S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pneumoniae (MICs = ≤0.25-64 µg/ml). Radezolid is also active against L. monocytogenes, S. aureus, L. pneumophila, and S. epidermidis in THP-1 macrophages (EC50s = 0.62, 0.63, 8.45, and 2.99 mg/L, respectively).{46801} It inhibits protein translation in isolated wild-type and linezolid-resistant S. aureus 70S ribosomes but not rabbit reticulocyte lysates (IC50s = 0.02, 0.03, and >2 µM, respectively).{46802} Radezolid is efficacious in a mouse model of S. pneumoniae-induced peritonitis with a 50% protective dose (PD50) value of 1.3 mg/kg per day.{46803}  

 

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SKU: 30092 - 1 mg Category:

Description

An oxazolidinone antibiotic; active against a variety of bacterial clinical isolates (MICs = ≤0.25-64 µg/ml); active against L. monocytogenes, S. aureus, L. pneumophila, and S. epidermidis in THP-1 macrophages (EC50s = 0.62, 0.63, 8.45, and 2.99 mg/L, respectively); inhibits protein translation in isolated wild-type and linezolid-resistant S. aureus ribosomes but not rabbit reticulocyte lysates (IC50s = 0.02, 0.03, and >2 µM, respectively); efficacious in a mouse model of S. pneumoniae-induced peritonitis (PD50 = 1.3 mg/kg per day)

Formal name: N-[[(5S)-3-[2-fluoro-4′-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1′-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

Synonyms:  Rx-01_667|RX-1741

Molecular weight: 438.5

CAS: 869884-78-6

Purity: ≥98%

Formulation: A solid

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