A RAD51 inhibitor (IC50 = 27.4 µM in a FRET-based DNA strand exchange assay); selective for RAD51 over RecA and RAD54 at concentrations up to 250 and 200 µM

RAD51 Inhibitor B02 – 25 mg

Brand:
Cayman
CAS:
1290541-46-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

RAD51 inhibitor B02 is an inhibitor of RAD51 recombinase (IC50 = 27.4 µM in a FRET-based DNA strand exchange assay), which is often overexpressed in cancer cells.{41309} It is selective for RAD51 over the E. coli homologue RecA at concentrations up to 250 µM and over RAD54 at concentrations up to 200 µM. RAD51 inhibitor B02 inhibits RAD51 binding to single-stranded DNA (ssDNA) and disrupts double-stranded DNA binding to the RAD51/ssDNA filament.{41310} It inhibits irradiation-induced RAD51 foci formation in HEK293 cells at a concentration of 50 µM. RAD51 inhibitor B02 increases sensitivity to cisplatin (Item No. 13119) in mouse embryonic fibroblasts in vitro and in an MDA-MB-231 mouse xenograft model when used at a dose of 50 mg/kg.{41311}  

 

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Description

A RAD51 inhibitor (IC50 = 27.4 µM in a FRET-based DNA strand exchange assay); selective for RAD51 over RecA and RAD54 at concentrations up to 250 and 200 µM, respectively; inhibits irradiation-induced RAD51 foci formation in HEK293 cells at a concentration of 50 µM; increases sensitivity to cisplatin in vitro and in an MDA-MB-231 mouse xenograft model when used at a dose of 50 mg/kg

Formal name: 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 339.4

CAS: 1290541-46-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair

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