A proton pump inhibitor; inhibits the gastric H+/K+ ATPase (IC50 = 72 nM); activated more rapidly and over a greater pH range than other proton pump inhibitors; inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula at 30 mg/kg; inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL)

Rabeprazole (sodium salt) – 10 mg

Brand:
Cayman
CAS:
117976-90-6
Storage:
-20
UN-No:
Non-Hazardous - /

Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM).{23855} It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole (Item No. 14880), lansoprazole (Item No. 13627), and pantoprazole (Item No. 21345).{23854} Rabeprazole (30 mg/kg) inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula.{47042} It also inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL).{23854} Formulations containing rabeprazole have been used in the treatment of ulcers, pathological hypersecretory conditions, and gastroesophageal reflux disease (GERD).  

 

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Description

A proton pump inhibitor; inhibits the gastric H+/K+ ATPase (IC50 = 72 nM); activated more rapidly and over a greater pH range than other proton pump inhibitors; inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula at 30 mg/kg; inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL)

Formal name: 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole, monosodium salt

Synonyms:  E 3810|LY307640

Molecular weight: 381.4

CAS: 117976-90-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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