A Syk inhibitor (IC50 = 226 nM in cultured human mast cells); acts in an ATP-competitive and reversible manner (Ki = 96 nM); inhibits anti-IgE cross-linking-induced mast cell and basophil degranulation (EC50 = 353 and 280 nM

R112 – 5 mg

Brand:
Cayman
CAS:
575474-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM).{46184} It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; Item No. 20210) and decreases cytokine levels in cultured human mast cells.  

 

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SKU: 22929 - 5 mg Category:

Description

A Syk inhibitor (IC50 = 226 nM in cultured human mast cells); acts in an ATP-competitive and reversible manner (Ki = 96 nM); inhibits anti-IgE cross-linking-induced mast cell and basophil degranulation (EC50 = 353 and 280 nM, respectively); inhibits allergen-induced inhibits basophil degranulation (EC50 = 490 nM)

Formal name: 3,3′-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol

Synonyms: 

Molecular weight: 312.3

CAS: 575474-82-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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