An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM

R-(-)-Phenylephrine (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
61-76-7
Storage:
-20
UN-No:
Non-Hazardous - /

R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine (Item No. 16673).{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122}  

 

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Description

An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively); frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents

Formal name: 3-hydroxy-α-[(methylamino)methyl]-benzenemethanol, monohydrochloride

Synonyms:  L-Phenylephrine

Molecular weight: 203.7

CAS: 61-76-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasoconstriction

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