A potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT)

(R)-Lisofylline – 10 mg

Brand:
Cayman
CAS:
100324-81-0
Storage:
-20
UN-No:
Non-Hazardous - /

LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.{17416,18148} (R)-LSF is the biologically active isomer of LSF.{17416,18148} It is a potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.{17415} (R)-LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits interleukin 12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.{17414,17416}  

 

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Description

A potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock; suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12 signaling, and enhances glucose-stimulated β-cell insulin secretion; reduces the onset of diabetes in a non-obese diabetic mouse model

Formal name: 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione

Synonyms:  (−)-Lisofylline|(R)-LSF

Molecular weight: 280.3

CAS: 100324-81-0

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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