A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC50 = 3.3 µM); demonstrates antibacterial activity against E. coli

(R)-Gyramide A (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1793050-70-0
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-Gyramide A is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM.{29792} It does not affect the closely related enzyme topoisomerase IV.{29793} (R)-Gyramide A demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 µM).{29792}  

 

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Description

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC50 = 3.3 µM); demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 µM)

Formal name: 5-fluoro-2-methyl-N-[(3R)-1-[[4-(1-methylethoxy)phenyl]methyl]-3-pyrrolidinyl]-benzenesulfonamide, monohydrochloride

Synonyms:  (R)-534F6

Molecular weight: 443

CAS: 1793050-70-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Typhoid

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