An antagonist of TNF-αRI; inhibits ICAM-1 expression induced by TNF-α and IL-1β (EC50s = 2.45 and 3.79 µM); inhibits IκBα degradation induced by TNF-α; disrupts the interaction of TNF-αRI with RIP1 and TRADD

R-8507 – 10 mg

Brand:
Cayman
CAS:
338773-13-0
Storage:
-20
UN-No:
Non-Hazardous - /

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).{27910} It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.  

 

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Description

An antagonist of TNF-αRI; inhibits ICAM-1 expression induced by TNF-α and IL-1β (EC50s = 2.45 and 3.79 µM); inhibits IκBα degradation induced by TNF-α; disrupts the interaction of TNF-αRI with RIP1 and TRADD

Formal name: 1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Synonyms: 

Molecular weight: 348.7

CAS: 338773-13-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity

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