A cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM)

R-7050 – 10 mg

Brand:
Cayman
CAS:
303997-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

R-7050 is a cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM).{27910} It blocks TNF-α-induced binding of TNF-α receptor I with TNF-α receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor complex.{27910} R-7050 is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.{27910} It has been used to investigate the role of TNF-α in neurovascular injury and mycotoxin-induced anorexia.{27911,27912}  

 

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Description

A cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM), blocking TNF-α-induced binding of TNF-α receptor I with TRADD and RIP1

Formal name: 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

Synonyms:  TNF-α Antagonist III

Molecular weight: 380.8

CAS: 303997-35-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience

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