A calcimimetic compound that can allosterically activate or positively modulate the human CaSR; dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials

R-568 – 1 mg

Brand:
Cayman
CAS:
177172-49-5
Storage:
-20
UN-No:
Non-Hazardous - /

Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis.{29237,26276} Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration.{29237,26276} R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR.{30711,30710,26280} It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials.{30711} R-568 is used in research to explore novel actions of CaSR.{30709,30708}  

 

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Description

A calcimimetic compound that can allosterically activate or positively modulate the human CaSR; dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials

Formal name: 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine, monohydrochloride

Synonyms:  KRN 568|NPS R-568|Tecalcet

Molecular weight: 340.3

CAS: 177172-49-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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