A histamine H3 receptor agonist; inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats from 0.25-2 mg/kg; inhibits gastric acid secretion in rats when administered intracerebroventricularly from 0.5-50 nmol; reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice

R-(−)-α-Methylhistamine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
75614-89-0
Storage:
-20
UN-No:
Non-Hazardous - /

R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant.{43477}  

 

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Description

A histamine H3 receptor agonist; inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats from 0.25-2 mg/kg; inhibits gastric acid secretion in rats when administered intracerebroventricularly from 0.5-50 nmol; reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively; decreases freezing time in a conditioned fear stress test in rats; acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund’s adjuvant

Formal name: (αR)-methyl-1H-imidazole-5-ethanamine, dihydrochloride

Synonyms: 

Molecular weight: 198.1

CAS: 75614-89-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Pain Research

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