A selective FLT3 inhibitor (Kd = 1.6 nM) that inhibits the proliferation of MV4-11 cells both in vitro (IC50 = 0.56 nM) and in in vivo mouse models of FLT3-ITD acute myeloid leukemia

Quizartinib – 500 µg

Brand:
Cayman
CAS:
950769-58-1
Storage:
-20
UN-No:
Non-Hazardous - /

Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.{30966,30967} It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of 0.56 nM.{30966} At 1 mg/kg/day, quizartinib has been shown to extend survival in a mouse model of FLT3-ITD acute myeloid leukemia and to eradicate tumors in an FLT3-dependent mouse xenograft model at 10 mg/kg.{30967}  

 

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Description

A selective FLT3 inhibitor (Kd = 1.6 nM) that inhibits the proliferation of MV4-11 cells both in vitro (IC50 = 0.56 nM) and in in vivo mouse models of FLT3-ITD acute myeloid leukemia

Formal name: N-​[5-​(1,​1-​dimethylethyl)​-​3-​isoxazolyl]​-​N’-​[4-​[7-​[2-​(4-​morpholinyl)​ethoxy]​imidazo[2,​1-​b]​benzothiazol-​2-​yl]​phenyl]​-urea

Synonyms:  AC220

Molecular weight: 560.7

CAS: 950769-58-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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