An endogenous agonist at NMDA receptors generated through the metabolism of tryptophan in the kynurenine pathway; generates reactive oxygen species

Quinolinic Acid – 50 g

Brand:
Cayman
CAS:
89-00-9
Storage:
-20
UN-No:
Non-Hazardous - /

Quinolinic acid is an endogenous agonist at NMDA receptors that is generated through the metabolism of tryptophan in the kynurenine pathway.{23856} By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders.{20572} Quinolinic acid can also generate reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.{6411,5945,23005}  

 

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Description

An endogenous agonist at NMDA receptors generated through the metabolism of tryptophan in the kynurenine pathway; generates reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins

Formal name: 2,3-pyridinedicarboxylic acid

Synonyms:  NSC 13127|NSC 18836|NSC 403247

Molecular weight: 167.1

CAS: 89-00-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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