An antimalarial agent (MICs = 10-500 nM for P. falciparum); inhibits hemozoin formation in purified trophozoites

Quinine – 5 g

Brand:
Cayman
CAS:
130-95-0
Storage:
-20
UN-No:
Non-Hazardous - /

Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.{39572} It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine (Item No. 14194).{38381} In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.{39573} Formulations containing quinine have been used in the treatment of uncomplicated malaria.  

 

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SKU: 23958 - 5 g Category:

Description

An antimalarial agent (MICs = 10-500 nM for P. falciparum); inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme; reduces mouse P. berghei parasite load in the blood with an MED of 150 mg/kg

Formal name: (8α,9R)-6′-methoxy-cinchonan-9-ol

Synonyms:  NSC 192949

Molecular weight: 324.4

CAS: 130-95-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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