An antiarrhythmic agent; a stereoisomer of quinine; blocks Nav1.5 in a use-dependent manner; decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes; inhibits KKr

Quinidine – 25 g

Brand:
Cayman
CAS:
56-54-2
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.  

 

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Description

An antiarrhythmic agent; a stereoisomer of quinine; blocks Nav1.5 in a use-dependent manner; decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes; inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM) and can induce torsade de pointes in isolated rabbit hearts at 1 µM; induces QT prolongation in dogs; binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM)

Formal name: 6′-methoxy-cinchonan-9S-ol

Synonyms:  (+)-Quinidine|β-Quinidine

Molecular weight: 324.4

CAS: 56-54-2

Purity: ≥95% (may contain up to 15% hydroquinidine)

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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