A prodrug to the ACE inhibitor quinaprilat; inhibits the contractile and pressor effects of angiotensin I in rabbit aorta and in rats

Quinapril (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
82586-55-8
Storage:
-20
UN-No:
Non-Hazardous - /

Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}  

 

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Description

A prodrug to the ACE inhibitor quinaprilat; inhibits the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and lowers blood pressure in rodent and dog models of hypertension

Formal name: 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride

Synonyms:  CI-906|PD 109452-2

Molecular weight: 475

CAS: 82586-55-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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