An autophagy inhibitor that has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification at a minimum concentration of 0.5 µM

Quinacrine analog 34 – 5 mg

Brand:
Cayman
CAS:
1411646-44-0
Storage:
-20
UN-No:
Non-Hazardous - /

Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}  

 

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Description

An autophagy inhibitor that has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification at a minimum concentration of 0.5 µM

Formal name: 6-chloro-1,2,3,4-tetrahydro-N-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridinamine

Synonyms: 

Molecular weight: 358.9

CAS: 1411646-44-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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