A cell-permeant precursor for the high affinity fluorescent calcium indicator quin-2 (Kd = 115 nM for calcium); ideal for monitoring low levels of calcium

Quin-2 AM – 1 mg

Brand:
Cayman
CAS:
83104-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Item No. 20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.{31959} It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.{31959} High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.{31959,23813} Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.  

 

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SKU: 20422 - Category:

Description

A cell-permeant precursor for the high affinity fluorescent calcium indicator quin-2 (Kd = 115 nM for calcium); ideal for monitoring low levels of calcium, as are found in resting cells; may be used to buffer intracellular calcium transients

Formal name: N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-glycine(acetyloxy)methyl ester

Synonyms:  Quin-2 Acetoxymethyl ester

Molecular weight: 829.8

CAS: 83104-85-2

Purity: ≥90%

Formulation: A solid

Application|Flow Cytometry||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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