An atypical

Quetiapine (hemifumarate) – 1 g

Brand:
Cayman
CAS:
111974-72-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}  

 

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Description

An atypical, second generation antipsychotic compound that has effects at multiple receptors; antagonizes dopamine D1, D2, and D3 receptors, serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors, and α1A, α1B, and α2C adrenergic receptors ,

Formal name: 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol, 2E-butenedioate (2:1)

Synonyms:  ICI 204636

Molecular weight: 441.5

CAS: 111974-72-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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