A selective PDE3 inhibitor with positive inotropic and vasodilating properties; induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM); increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner at 10-300 μg/kg

Quazinone – 10 mg

Brand:
Cayman
CAS:
70018-51-8
Storage:
-20
UN-No:
Non-Hazardous - /

Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).{45607} Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}  

 

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Description

A selective PDE3 inhibitor with positive inotropic and vasodilating properties; induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM); increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner at 10-300 μg/kg, as well as decreases systolic and diastolic blood pressure; inhibits DNA synthesis induced by PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner

Formal name: (3R)-6-chloro-1,5-dihydro-3-methyl-imidazo[2,1-b]quinazolin-2(3H)-one

Synonyms:  Ro 13-6438

Molecular weight: 235.7

CAS: 70018-51-8

Purity: ≥98%

Formulation: A solid

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