An ARFGAP inhibitor; increases ARF activity in NIH3T3 cells at a concentration of 1 μM; activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM); inhibits ARFGAP1 (EC50 = 1.5 μM in an enzyme assay); inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1

QS11 – 5 mg

Brand:
Cayman
CAS:
944328-88-5
Storage:
-20
UN-No:
Non-Hazardous - /

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM.{38424} It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.{38424,38425}  

 

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Description

An ARFGAP inhibitor; increases ARF activity in NIH3T3 cells at a concentration of 1 μM; activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM); inhibits ARFGAP1 (EC50 = 1.5 μM in an enzyme assay); inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1,

Formal name: βS-[[9-([1,1′-biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]-benzenepropanol

Synonyms: 

Molecular weight: 567.7

CAS: 944328-88-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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