An inhibitor of NF-κB activation with an IC50 value of 11 nM in human Jurkat cells; inhibits TNF-α production from LPS-stimulated mouse splenocytes (IC50 = 7 nM)

QNZ – 1 mg

Brand:
Cayman
CAS:
545380-34-5
Storage:
-20
UN-No:
Non-Hazardous - /

Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}  

 

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SKU: 10006734 - 1 mg Category:

Description

An inhibitor of NF-κB activation with an IC50 value of 11 nM in human Jurkat cells; inhibits TNF-α production from LPS-stimulated mouse splenocytes (IC50 = 7 nM)

Formal name: N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine

Synonyms:  CAY10470

Molecular weight: 356.4

CAS: 545380-34-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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