An anthelmintic and anticancer agent; dietary administration reduces worm burden in mouse models of N. dubius

Pyrvinium (pamoate) – 50 mg

Brand:
Cayman
CAS:
3546-41-6
Storage:
-20
UN-No:
Non-Hazardous - /

Pyrvinium is an anthelmintic and anticancer agent.{61022,61023} Dietary administration of pyrvinium reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively) but is lethal to mice at higher concentrations (LC50 = 600 ppm).{61022} Pyrvinium (1 μg/ml) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium.{61023} It reduces tumor growth in a PANC-1 mouse xenograft model when administered at a dose of 100 μg/mouse per day. Pyrvinium (10 nM) also binds to and activates casein kinase 1α (CK1α).{60124} It inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner. Formulations containing pyrvinium were previously used in the treatment of pinworm infections.  

 

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Description

An anthelmintic and anticancer agent; dietary administration reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively); lethal to mice at higher concentrations (LC50 = 600 ppm in the diet); induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium, but not serum- or amino acid-deficient medium or complete medium, at 1 μg/ml; reduces tumor growth in a PANC-1 mouse xenograft model at 100 μg/mouse per day; binds to and activates CK1α at 10 nM; inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner

Formal name: 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium

Synonyms:  NSC 223622

Molecular weight: 575.7

CAS: 3546-41-6

Purity: ≥95%

Formulation: A solid

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