A quinone with diverse biological activities; inhibits fibril formation by Aβ42 and mouse prion protein at 100 and 300 μM; stimulates cell proliferation

Pyrroloquinoline quinone – 1 mg

Brand:
Cayman
CAS:
72909-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

Pyrroloquinoline quinone (PQQ) is a quinone and redox enzyme cofactor that has been found in a variety of bacteria and has diverse biological activities.{43289,43290,43291,43292,43293} It inhibits fibril formation by the amyloid proteins amyloid-β (1-42) (Aβ42) and mouse prion protein when used at a concentrations of 100 and 300 μM.{43289} PQQ stimulates cell proliferation, reduces glutamate-induced production of reactive oxygen species (ROS), necrosis, and caspase-3 activity, and increases activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in neural stem and progenitor cells.{43290} It inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) and suppresses LPS-induced expression of the pro-inflammatory mediators iNOS, COX-2, TNF-α, IL-1β, IL-6, MCP-1, and MIP-1α in primary microglia.{43294} In vivo, PQQ (3 and 10 mg/kg) reduces Iba-1 expression, a marker of microglial activation, in the cerebral cortex and hippocampal dentate gyrus in mice. PQQ decreases the number of hepatic cells positive for α-smooth muscle actin (α-SMA) and reduces collagen deposition and hepatic hydroxyproline levels in a mouse model of liver fibrosis.{43292} It also decreases serum glucose and total cholesterol levels, increases brain SOD, CAT, and GPX activities, and decreases brain lipid hydroperoxide levels in mice with diabetes induced by streptozotocin (Item No. 13104).{43293}  

 

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Description

A quinone with diverse biological activities; inhibits fibril formation by Aβ42 and mouse prion protein at 100 and 300 μM; stimulates cell proliferation, reduces glutamate-induced production of ROS, necrosis, and caspase-3 activity and increases activity of SOD, CAT, and GPX in neural stem and progenitor cells; inhibits LPS-induced production of NO and PGE2 and suppresses LPS-induced expression of various pro-inflammatory mediators in primary microglia; reduces Iba-1 expression in the cerebral cortex and hippocampal dentate gyrus in mice at 3 and 10 mg/kg; decreases the number of α-SMA-positive hepatic cells, collagen deposition, and hepatic hydroxyproline levels in a mouse model of liver fibrosis; decreases serum glucose and total cholesterol levels, increases brain SOD, CAT, and GPX activities, and decreases brain lipid hydroperoxide levels in mice with streptozotocin-induced diabetes

Formal name: 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Synonyms:  PQQ

Molecular weight: 330.2

CAS: 72909-34-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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