A potent antimalarial compound that inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM; effective against artemisinin-resistant malaria and can be used in combination therapy

Pyronaridine (phosphate) – 250 mg

Brand:
Cayman
CAS:
76748-86-2
Storage:
-20
UN-No:
Non-Hazardous - /

Pyronaridine (PND) is a potent antimalarial compound developed in China over 40 years ago.{26530} It inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM.{26533,26534} PND is highly effective against artemisinin-resistant malaria and can be used in combination therapy, particularly with the artemisinin derivative, artesunate (Item No. 11817).{26531,26532} PND, alone or in combination with artesunate, prevents recrudescence of parasites.{26531} Resistance to pyronaridine may be linked to genetic variations in the P. falciparum multidrug resistance protein 1.{26534}  

 

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Description

A potent antimalarial compound that inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM; effective against artemisinin-resistant malaria and can be used in combination therapy, particularly with artesunate

Formal name: 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-phenol, tetraphosphate

Synonyms:  PND

Molecular weight: 910

CAS: 76748-86-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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