A fungal metabolite with diverse biological activities; inhibits production of TBARS in vitro (IC50 = 0.55 μg/ml); inhibits AAPH-induced hemolysis in rat erythrocytes (IC50 = 1.95 μg/ml); is active against C. albicans (MIC = 1.64 μg/ml); cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 μg/ml); inhibits gelatinase A (IC50 = 15.2 μM)

Pyridoxatin – 1 mg

Brand:
Cayman
CAS:
135529-30-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pyridoxatin is a fungal metabolite originally isolated from Acremonium with diverse biological activities.{43929} It inhibits production of thiobarbituric acid reactive substance (TBARS) in vitro (IC50 = 0.55 μg/ml). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH in rat erythrocytes (IC50 = 1.95 μg/ml). It is active against C. albicans (MIC = 1.64 μg/ml). Pyridoxatin is cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 μg/ml).{43930} It also inhibits gelatinase A (IC50 = 15.2 μM).  

 

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SKU: 27607 - 1 mg Category:

Description

A fungal metabolite with diverse biological activities; inhibits production of TBARS in vitro (IC50 = 0.55 μg/ml); inhibits AAPH-induced hemolysis in rat erythrocytes (IC50 = 1.95 μg/ml); is active against C. albicans (MIC = 1.64 μg/ml); cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 μg/ml); inhibits gelatinase A (IC50 = 15.2 μM)

Formal name: 3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxy-2(1H)-pyridinone

Synonyms: 

Molecular weight: 263.3

CAS: 135529-30-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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