A cholinesterase inhibitor (IC50s = 0.35 and 1.0 μM for human AChE and BChE

Pyridostigmine (bromide) – 500 mg

Brand:
Cayman
CAS:
101-26-8
Storage:
-20
UN-No:
- 2811 / 6.1

Pyridostigmine is a cholinesterase (ChE) inhibitor with IC50 values of 0.35 and 1.0 μM for human acetyl ChE (AChE) and butyryl ChE (BChE), respectively.{38659} Ex vivo, pyridostigmine protects bovine red blood cells from toxic and irreversible AChE inhibition by the organophosphates diisopropyl fluorophosphates, chlorpyrifos (Item No. 21412), diazinon (Item No. 23769), paraoxon, and malaoxon.{38660} It also binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction.{38662} Formulations containing pyridostigmine have been used to treat myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.  

 

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SKU: 23831 - 500 mg Category:

Description

A cholinesterase inhibitor (IC50s = 0.35 and 1.0 μM for human AChE and BChE, respectively); protects bovine red blood cells from toxic and irreversible AChE inhibition by organophosphates; binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers; prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction (3 mg/kg per day for four weeks)

Formal name: 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-pyridinium, monobromide

Synonyms:  NSC 679759|Ro 1-5130

Molecular weight: 261.1

CAS: 101-26-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cardiovascular System|Blood||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Neuroscience||Research Area|Toxicology|Environmental

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