A structurally unusual antibiotic that inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA

Pyridomycin – 2.5 mg

Brand:
Cayman
CAS:
18791-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid.{27783} It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml).{27784}  

 

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Description

A structurally unusual antibiotic that inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml)

Formal name: 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-2-pyridinecarboxamide

Synonyms:  Erizomycin|NSC 246134

Molecular weight: 540.6

CAS: 18791-21-4

Purity: ≥95%

Formulation: A residue

Product Type|Biochemicals|Antibiotics|Polypeptides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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