An anthelmintic and agonist of nAChRs; activates chimeric C. elegans α7-nAChR expressed in BOSC cells (EC50 = 40 μM); induces contraction of A. suum muscle (EC50 = 57.5 nM); decreases survival of A. ceylanicum

Pyrantel (pamoate) – 10 g

Brand:
Cayman
CAS:
22204-24-6
Storage:
-20
UN-No:
Non-Hazardous - /

Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.  

 

Available on backorder

Add to quotes
SKU: 27368 - 10 g Category:

Description

An anthelmintic and agonist of nAChRs; activates chimeric C. elegans α7-nAChR expressed in BOSC cells (EC50 = 40 μM); induces contraction of A. suum muscle (EC50 = 57.5 nM); decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively) in vitro; decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice at 6 mg/kg

Formal name: 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1)

Synonyms:  CP 10423-16

Molecular weight: 594.7

CAS: 22204-24-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 100 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page