A positive allosteric modulator of NR2C subunit-containing NMDARs; enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM); selective for NR2C subunit-containing NMDA receptors over NR2A-

PYD-106 – 1 mg

Brand:
Cayman
CAS:
1560894-05-4
Storage:
-20
UN-No:
Non-Hazardous - /

PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).{48963} It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.  

 

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SKU: 28837 - 1 mg Category:

Description

A positive allosteric modulator of NR2C subunit-containing NMDARs; enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM); selective for NR2C subunit-containing NMDA receptors over NR2A-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM

Formal name: 4-[3-acetyl-2,5-dihydro-4-hydroxy-1-[2-(2-methyl-1H-indol-3-yl)ethyl]-5-oxo-1H-pyrrol-2-yl]-benzoic acid, methyl ester

Synonyms: 

Molecular weight: 432.5

CAS: 1560894-05-4

Purity: ≥98%

Formulation: A solid

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