Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells

PX-478 – 5 mg

Brand:
Cayman
CAS:
685898-44-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}  

 

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SKU: 10005189 - 5 mg Category:

Description

Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes; increases chemo- or radiosensitivity of tumors

Formal name: 4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride

Synonyms: 

Molecular weight: 394.1

CAS: 685898-44-6

Purity: ≥95%

Formulation: A semi-solid

Product Type|Biochemicals|Small Molecule Inhibitors|Prolyl Hydroxylation Enzymes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors|HIF-1α||Research Area|Cancer|Tumor Microenvironment

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