A PI3K inhibitor; inhibits PI3Kα

PX-13-17OH – 5 mg

Brand:
Cayman
CAS:
884539-95-1
Storage:
-20
UN-No:
Non-Hazardous - /

PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.  

 

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Description

A PI3K inhibitor; inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM); 420-fold selective for PI3K in a panel of 20 lipid and protein kinases; inhibits phosphorylation of Akt and S6K in PTEN-negative U87MG cells at 0.03-1 µg/ml; inhibits tumor growth in a U87MG mouse xenograft model at 2.5-10 mg/kg

Formal name: (1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione

Synonyms: 

Molecular weight: 546.7

CAS: 884539-95-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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