A 2

Purmorphamine – 10 mg

Brand:
Cayman
CAS:
483367-10-8
Storage:
-20
UN-No:
Non-Hazardous - /

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}  

 

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SKU: 10009634 - 10 mg Category:

Description

A 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts; binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway

Formal name: 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Synonyms: 

Molecular weight: 520.6

CAS: 483367-10-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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