A triterpenoid saponin; inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV

Pulchinenoside A – 50 mg

Brand:
Cayman
CAS:
129724-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.{48595,48596} It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.{48596} Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin (5-HT; Item No. 14332), 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889), and norepinephrine (Item No. 16673) in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.{48595}  

 

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Description

A triterpenoid saponin; inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death at 30 μM; increases the levels of 5-HT, 5-HIAA, and norepinephrine in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice at 30 and 100 mg/kg; reduces the time spent immobile in the forced swim test in mice at 30 and 100 mg/kg; increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg; reduces infarct volume in an MCAO rat model of ischemia at 12.6 and 25.2 mg/kg; induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner

Formal name: (3β,4α)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-lup-20(29)-en-28-oic acid

Synonyms:  Anemoside A3

Molecular weight: 751

CAS: 129724-84-1

Purity: ≥90%

Formulation: A solid

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