A GRP94 inhibitor (IC50 = 0.22 µM); selective for GRP94 over Hsp90α

PU-WS13 – 1 mg

Brand:
Cayman
CAS:
1454619-14-7
Storage:
-20
UN-No:
Non-Hazardous - /

PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 µM).{54397} It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively). PU-WS13 (0.5, 2.5, and 12.5 µM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells.{30011} It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.{30009}  

 

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Description

A GRP94 inhibitor (IC50 = 0.22 µM); selective for GRP94 over Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 µM, respectively); induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells at 0.5, 2.5, and 12.5 µM; induces apoptosis and necrosis in multiple myeloma cells

Formal name: 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

Synonyms:  WS13

Molecular weight: 411.4

CAS: 1454619-14-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cell Biology|Cellular Chaperones

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