A cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms

PTP1B Inhibitor – 5 mg

Brand:
Cayman
CAS:
765317-72-4
Storage:
-20
UN-No:
Non-Hazardous - /

Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.{15396,26227} PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).{26228} It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.{26228,26226} PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.{26228}  

 

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Description

A cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively); binds reversibly and non-competitively; selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin

Formal name: 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

Synonyms:  Protein Tyrosine Phosphatase 1B Inhibitor

Molecular weight: 741.5

CAS: 765317-72-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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