A photoreversible covalent inhibitor of PTPs; binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols

PTP Inhibitor III – 1 mg

Brand:
Cayman
CAS:
29936-81-0
Storage:
-80
UN-No:
Non-Hazardous - /

PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).{31401} It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.{31402}  

 

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Description

A photoreversible covalent inhibitor of PTPs; binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm)

Formal name: 2-[4-(2-bromoacetyl)phenoxy]-acetic acid

Synonyms:  Protein Tyrosine Phosphatase Inhibitor III|α-Bromo-4-(carboxymethoxy)acetophenone

Molecular weight: 273.1

CAS: 29936-81-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Signaling

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