A cell-permeable inhibitor of the catalytic domain of SHP-1

PTP Inhibitor II – 5 g

Brand:
Cayman
CAS:
2632-13-5
Storage:
22
UN-No:
- 3261 / 8

PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}  

 

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SKU: 20629 - Category:

Description

A cell-permeable inhibitor of the catalytic domain of SHP-1, SHP-1(ΔSH2) (Ki = 128 µM)

Formal name: 2-bromo-1-(4-methoxyphenyl)-ethanone

Synonyms:  4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II|α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone

Molecular weight: 229.1

CAS: 2632-13-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Signaling

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