A cell-permeable inhibitor of the catalytic domain of SHP-1

PTP Inhibitor I – 50 g

Brand:
Cayman
CAS:
2491-38-5
Storage:
22
UN-No:
Non-Hazardous - /

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 µM and PTP1B with a Ki value of 42 µM.{31401} SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}  

 

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SKU: 19766 - Category:

Description

A cell-permeable inhibitor of the catalytic domain of SHP-1, SHP-1(ΔSH2) (Ki = 43 µM), and PTP1B (Ki = 42 µM)

Formal name: 2-bromo-1-(4-hydroxyphenyl)-ethanone

Synonyms:  2-Bromo-4′-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II|α-Bromo-4-hydroxyacetophenone

Molecular weight: 215

CAS: 2491-38-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Signaling

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