Immunogen: Peptide from the internal region of human PTEN • Host: Rabbit • Species Reactivity: (+) Human

PTEN Polyclonal Antibody – 500 µl

Brand:
Cayman
Storage:

Phosphatase and tensin homolog (PTEN) is a tumor suppressor with roles in cell division, cell migration, and apoptosis.{13065,54452,54453,54454} It is ubiquitously expressed and localized to the cytosol and nucleus where it dephosphorylates phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-(3,4)-diphosphate (PIP2) to antagonize PI3K signaling and regulates spliceosome assembly and pre-mRNA splicing, respectively.{54452} PTEN inhibits cell cycle progression and induces apoptosis, as well as inhibits cell adhesion and migration in vitro.{13040} PTEN deletions have been found in various cancers, including glioblastomas and prostate, breast, and kidney cells. Germline mutations in PTEN induce a variety of syndromes, including Cowden, Bannayan-Riley-Ruvalcaba, Proteus, and Proteus-like syndromes, that are characterized by increased risk of cancers, developmental delays, autism spectrum disorders, and macroencephaly.{54454} Cayman’s PTEN Polyclonal antibody can be used for immunohistochemistry (IHC) and Western blot applications.  

 

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SKU: 10005059 - 500 µl Category:

Description

Immunogen: Peptide from the internal region of human PTEN • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat • Cross Reactivity: (+)-PTEN • Applications: IHC, WB

Synonyms: MMAC1|Mutated in Multiple Advanced Cancers 1|Phosphatidylinositol-(3,4,5)-Triphosphate 3-Phosphatase and Dual-specificity Protein Phosphatase|TEP1

Immunogen: Peptide from the internal region of human PTEN

Formulation: 500 µl of peptide affinity-purifed IgG

Isotype:

Applications: IHC and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Neuroscience

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