A synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions; features the same inositol and diacylglycerol stereochemistry as the natural compound; the short fatty acid chains give it higher solubility in aqueous media

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) – 500 µg

Brand:
Cayman
CAS:
799268-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{16567,16566} PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC).{13721} Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains.{5241}{8674} Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking.{16565} PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.  

 

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SKU: 10008390 - 500 µg Category:

Description

A synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions; features the same inositol and diacylglycerol stereochemistry as the natural compound; the short fatty acid chains give it higher solubility in aqueous media, as compared to naturally-occurring PIP3.

Formal name: 1-(1,2R-dihexanoylphosphatidyl)inositol-3,4,5-triphosphate, tetraammonium salt

Synonyms:  DHPI-3,4,5-P3|Phosphatidylinositol-3,4,5-triphosphate C-6|PIP3C-16

Molecular weight: 838.6

CAS: 799268-62-5

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Cell Biology|Inositol Phosphates||Research Area|Lipid Biochemistry|Glycerophospholipids

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