A BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs CIC growth; reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo

PTC-209 – 25 mg

Brand:
Cayman
CAS:
315704-66-6
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth.{28288} It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.{28288}  

 

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Description

A BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs CIC growth; reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo

Formal name: N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Synonyms: 

Molecular weight: 495.2

CAS: 315704-66-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Cycle

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