A CB1 receptor antagonist; selective for CB1 over CB2 receptors in HEK293 cells overexpressing the human receptors (IC50s = 0.1 and ≥10 µM

PSNCBAM-1 – 5 mg

Brand:
Cayman
CAS:
877202-74-9
Storage:
-20
UN-No:
Non-Hazardous - /

PSNCBAM-1 is a cannabinoid (CB) receptor 1 antagonist that is selective for CB1 over CB2 receptors in HEK293 cells overexpressing the human receptors (IC50s = 0.1 and ≥10 µM, respectively, in a GTP binding assay).{42910} PSNCBAM-1 inhibits activation of the human CB1 receptor induced by (±)-CP 55,940 (Item No. 13241), anandamide (AEA; Item No. 90050), and 2-arachidonoyl glycerol (2-AG; Item No. 62160) in yeast expressing human CB1 (IC50s = 45, 37 and 230 nM, respectively). PSNCBAM-1 (30 mg/kg, i.p.) reduces food intake within 2 hours and decreases body weight by 24 hours after administration in male rats.  

 

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SKU: 25855 - 5 mg Category:

Description

A CB1 receptor antagonist; selective for CB1 over CB2 receptors in HEK293 cells overexpressing the human receptors (IC50s = 0.1 and ≥10 µM, respectively); inhibits activation of the human CB1 receptor induced by (±)-CP 55,940, AEA, and 2-AG in yeast expressing human CB1 (IC50s = 45, 37 and 230 nM, respectively); reduces food intake within 2 hours and decreases body weight by 24 hours after administration in male rats at 30 mg/kg ,

Formal name: N-(4-chlorophenyl)-N’-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea

Synonyms: 

Molecular weight: 392.9

CAS: 877202-74-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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