Description
Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and a glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism encoded by FOLH1 in humans.{60113,60116} It is composed of a short intracellular domain, a transmembrane domain, and a large extracellular region that contains enzymatic domains.{60113,60114} PSMA is expressed in prostate epithelial cells and is highly overexpressed in prostate carcinomas. PSMA is also expressed in the central nervous system where it metabolizes N-acetyl-aspartyl-glutamate and in the proximal small intestine where it functions as a carboxypeptidase and a folate hydrolase, as well as in the neovasculature of various renal, colon, and breast carcinomas.{60116,60115} Expression of FOLH1 increases under androgen deprivation conditions in vitro and in vivo and positively correlates with cancer aggressiveness in patients with prostate cancer.{60113} PSMA positron emission tomography (PET) imaging is commonly used in the diagnosis and staging of prostate cancer, as well as to asses therapeutic response.{60114} Cayman’s PSMA (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms: Folate Hydrolase 1|FOLH1|GCPII|Glutamate Carboxypeptidase II|NAALADase|Prostate-specific Membrane Antigen
Immunogen: A peptide from the C-terminal region of human PSMA
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC, WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Neuroscience
