The deaminated/inactive derivative of PSI-6130

PSI-6206 – 100 mg

Brand:
Cayman
CAS:
863329-66-2
Storage:
-20
UN-No:
Non-Hazardous - /

PSI-6206 is the deaminated derivative of PSI-6130, a selective inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase.{30617,30616} PSI-6206, itself, does not inhibit HCV replication in the HCV subgenomic replicon assay.{30617,30616} However, its triphosphate form, RO 2433-TP, does inhibit RNA synthesis by HCV polymerase (IC50 = 1.19 µM for inhibition of RNA synthesis activity of HCV replicase).{30617,30616}  

 

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Description

The deaminated/inactive derivative of PSI-6130, a selective inhibitor of HCV replication; can be triphosphorylated to form, RO 2433-TP, which inhibits RNA synthesis by HCV polymerase (IC50 = 1.19 µM)

Formal name: (2’R)-2′-deoxy-2′-fluoro-2′-methyl-uridine

Synonyms:  GS-331007|RO 2433

Molecular weight: 260.2

CAS: 863329-66-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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