Description
A nucleoside inhibitor of the NS5B RNA polymerase of HCV (Ki = 4.3 µM); inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 µM, respectively); inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 µM, and 0.20 to 0.43 µM, respectively, in the same assay; has little or no activity against WNV, DV, HIV, or HBV (EC90s = 46.3, >100, >100, and >10 µM, respectively),
Formal name: (2’R)-2′-deoxy-2′-fluoro-2′-methyl-cytidine
Synonyms:
Molecular weight: 259.2
CAS: 817204-33-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis
